sulfa drugs list terramycin

Sulfonamides are still used, but largely for treating urinary tract infections and preventing infection of burns. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. For people with renal dysfunction, taking this type of drug may require adjustments to dosages of other medications. Cephalosporins often treat gonorrhea, pelvic inflammatory disease, and sinusitis. [13][14] Sulfa had a central role in preventing wound infections during the war. Medically reviewed by Carmen Pope, BPharm. If an antibiotic is a combination drug, both ingredients will be listed. (2018). Research is mixed on whether there is an association between allergies to antibiotic sulfa drugs and nonantibiotic sulfa drugs. Elimination of 50% to 60% of the drug occurs in the urine within 72 hours. Last updated on Nov 10, 2021. Sulfa allergies and sulfite allergies arent the same thing. Dont take them for viral infections, such as a cold or the flu. Humans obtain folic acid from their diet, but bacteria need to synthesize it. Neither are their allergies. The diagnosis is made based on your symptoms, physical examination, and medical history. They are also a suitable option for people who are allergic to penicillin or cephalosporin. Sulfonamide allergies. What are antibiotics and how do they work? Sulfa allergy: Which medications should I avoid? A sulfa allergy is a rash or more serious reaction to sulfa drugs. The second is the N4 amino nitrogen that, in a stereospecific process, forms reactive metabolites that cause either direct cytotoxicity or immunologic response. Healthline Media does not provide medical advice, diagnosis, or treatment. Some healthcare providers may try a desensitization program for an allergy to sulfa drugs, prescribing small but increasing doses to improve tolerance. All rights reserved. Medications for a sulfa allergy in. It will not work for colds, flu, or other viral infections. Management depends on the type and severity of the reaction. However, there are several non-antibiotic sulfonamides that have been developed by exploiting observations made during the clinical evaluation of the antibiotic sulfonamides. From first exposure to life-threatening complications, learn how quickly an allergy attack can escalate and why it can become life threatening. Vuity Review: Is it worth it and alternatives The Eye Show. Lets discuss the details. Sulfonamide antimicrobials may be combined with trimethoprim to make them bactericidal (kill bacteria), because trimethoprim acts on a different enzyme in the folic acid synthesis pathway. Common penicillin antibiotics include: phenoxymethylpenicillin. Tell your doctor right away if youthink youre having a reaction to a sulfa drug. This article was most recently revised and updated by, https://www.britannica.com/science/sulfa-drug, National Center for Biotechnology Information - PubMed Central - Sulfonamide drugs: structure, antibacterial property, toxicity, and biophysical interactions, sulfa drug - Student Encyclopedia (Ages 11 and up). Macrolides, especially erythromycin and clarithromycin, can adversely interact with certain medications. Blaskovich MAT, et al. February 16, 2013 October 3, 2021. Angela_Howski. [3], Approximately 3% of the general population have adverse reactions when treated with sulfonamide antimicrobials. Allegra vs Zyrtec: What's the difference? It was discovered by the German physician and chemist Gerhard Domagk in 1935. ampicillin . However, its estimated that of those who have an adverse reaction, only 3 percent are true allergic reactions. These can be antibiotics, diuretics (water pills), eye drops, topical creams, and other types of drugs. Your doctor may recommend a desensitization procedure if you need medication and there isnt a sulfa-free alternative. Two regions of the sulfonamide antibiotic chemical structure are implicated in the hypersensitivity reactions associated with the class. Sulfonamides (sulphonamides) are a group of man-made (synthetic) medicines that contain the sulfonamide chemical group. Later, it was discovered by Daniel Bovet,[8] Federico Nitti, and Jacques and Thrse Trfoul, a French research team led by Ernest Fourneau at the Pasteur Institute, that the drug was metabolized into two parts inside the body, releasing from the inactive dye portion a smaller, colorless, active compound called sulfanilamide. Tetracycline is a naturally occurring molecule derived from Streptomyces bacteria . For a complete list of severe side effects, please refer to the individual drug monographs. This medicine is available only with your doctor's prescription. By Shamard Charles, MD, MPH Sulfanilamide was the first sulfonamide developed in 1906, although it was not used as an antimicrobial agent until the late 1930s. There is no test for a sulfa allergy, so people usually find out that they have an allergy after an adverse medical reaction to a drug, supplement, or personal care product. More InfoSee Prices Bleph-10 as low as $142 Ones that may be safe to take include: Glyburide (Glynase, Diabeta), a drug for diabetes, Celecoxib (Celebrex), a nonsteroidal anti-inflammatory drug (NSAID), Sumatriptan (Imitrex, Sumavel Dosepro, Zecuity), a migraine drug, Water pills, or diuretics, including furosemide (Lasix) and hydrochlorothiazide (Microzide). the unsubscribe link in the e-mail. This led to the passage of the Federal Food, Drug, and Cosmetic Act in 1938 in the United States. Always make sure that your healthcare providers are aware of your sulfa allergy so medications containing sulfa can be avoided. They may also be called sulfa drugs. Sulfamethoxazole-trimethoprim (Septra, Bactrim) Erythromycin-sulfisoxazole Other medications that may cause a reaction Other types of sulfa medications may trigger a reaction in some people who have a sulfonamide antibiotic allergy: Sulfasalazine (Azulfidine), used to treat Crohn's disease, ulcerative colitis and rheumatoid arthritis They are also used in the treatment of certain forms of malaria. For ratings, users were asked how effective they found the medicine while considering positive/adverse effects and ease of use (1 = not effective, 10 = most effective). Antibiotics are a common, important group of medicines that treat bacterial infections. Make sure all healthcare providers, including your dentist and pharmacy, are aware of your drug allergies. "Mayo," "Mayo Clinic," "MayoClinic.org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research. Tetracyclines also treat inflammatory skin conditions, such as acne, rosacea, and perioral dermatitis. Sulfonamides are used in combination with pyrimethamine to treat protozoal diseases such as leishmaniasis and toxoplasmosis. Sulfites are chemicals that are often used as preservatives and antioxidants in foods (preventing browning and spoilage). Sulfites are preservatives that may seem impossible to avoid if you have a sulfite allergy or sensitivity. Available for Android and iOS devices. SULFADIAZINE is an sulfonamide antibiotic. See a healthcare provider if you have a reaction. Our editors will review what youve submitted and determine whether to revise the article. [18] A key component to the allergic response to sulfonamide antibiotics is the arylamine group at N4, found in sulfamethoxazole, sulfasalazine, sulfadiazine, and the anti-retrovirals amprenavir and fosamprenavir. This is called drug desensitization. Updates? The term sulfa allergy (or sulfur allergy) most commonly refers to an immunological response to sulfonamides, and it is a term that is often misused and misinterpreted. the drug sulfasalazine (Azulfidine), used in the treatment of rheumatoid arthritis, Crohn's disease, and ulcerative colitis the drug dapsone, used to treat dermatitis and some types of. Humans, in contrast to bacteria, acquire folate (vitamin B9) through the diet.[4]. Drug allergies. Sulfonylureas (eg, glipizide, glyburide [glibenclamide]) Sulfa-containing drugs (sulfacetamide, sulfadiazine, sulfamethoxazole [Gantanol], trimethoprim-sulfamethoxazole . Many people use the term sulfonamide imprecisely to refer only to antibiotics that have a sulfonamide functional group in their chemical structure. Trimethoprim-sulfamethoxazole is the most commonly used sulfa antibiotic. Sulfa drugs and sulfites are not related. This is not a complete list of side effects and others may occur. 2019;7(3):132. doi:10.3390/pharmacy7030132. When you visit the site, Dotdash Meredith and its partners may store or retrieve information on your browser, mostly in the form of cookies. The sulfones are related to the sulfonamides and are inhibitors of folic acid synthesis. A sulfa allergy is when you have an allergic reaction to drugs that contain sulfa. Sulfonamides are widely used to treat different microbial infections. We provide a detailed list of symptoms and complications of grass pollen allergies and tips for treatment. Could new onset dry eye symptoms be associated with ASIA syndrome after COVID vaccine? Some sulfonamides are also devoid of antibacterial activity, e.g., the anticonvulsant sultiame. If you have previously had a severe or anaphylactic reaction to sulfa drugs, carry an emergency epinephrine syringe (EpiPen). People with a sulfa allergy typically need to avoid sulfonamide antibiotics (antibiotics containing sulfa), including: Whether other nonantibiotic sulfa-containing drugs need to be avoided with sulfa allergy is unclear and considered on a case-by-case basis. Learn more. Vuity: do not use if you have or had high myopia (ie had LASIK or PRK for myopia) or family history of retinal hole, tear, detachment. Other reactions to sulfa drugs include headache, trouble sleeping, cloudy urine (crystalluria), and low blood counts. Tell them about any drug allergies so they can make a note in your medical records. A true sulfite allergy usually leads to asthma-like symptoms. This enzyme is critical for the synthesis of folate, an essential nutrient. The original antibacterial sulfonamides are synthetic (nonantibiotic) antimicrobial agents that contain the sulfonamide group. Allergic. These classes of drugs are generally broad-spectrum antibiotics that act on a wide range of bacterial types and are therefore employed in treating many kinds of bacterial infections. Jurairat J. Molina, MD, MBA is a board-certified allergist who has been practicing in field of allergy and clinical immunology for the past two decades. While the risk is low, people with an allergy to sulfa antibiotics may have a higher risk of reacting poorly to nonantibiotic sulfa drugs. However, they are linked with antimicrobial resistance, so you shouldnt take them unless its absolutely necessary. In people with asthma who have a sensitivity to sulfites, using an asthma inhaler may help with symptoms affecting breathing. Wear a medical bracelet. Sulfite allergies have no cure. These drugs include. But be sure to tell your doctor if you have a sulfa allergy before taking any of these. Study with Quizlet and memorize flashcards containing terms like The concept of a "magic bullet," a chemical that would selectively destroy pathogens without harming human cells, was put forth by Paul Blank 1 of 1, whose research sparked the era of modern antimicrobial chemotherapy., The first true antibiotic (a natural microbial product) to be used was, The screening of large numbers of soil . Other sulfa antibiotics include sulfadiazine, Silvadene (silver sulfadiazine), AVC Vaginal (sulfanilamide), and sulfacetamide (found in over-the-counter and prescription topical products). This can be frustrating, but eating fresh fruits and vegetables limits your sulfite intake to a negligible amount. Sulfonamide allergic reactions affect 1.5-3% of the population but are 10 times more likely in people with HIV. See additional information. Sulfonamides are mainly used to treat bacterial infections and some fungal infections. Healthline Media does not provide medical advice, diagnosis, or treatment. These are used for a range of conditions such as diabetes and pain relief. Reactions to sulfa drugs and sulfite develop within one to 48 hours of ingesting the substance. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Therefore, so won't necessarily be allergic to the other just because you've had a reaction to one. Sulfa allergies are different from sulfite allergies. Sulfonamides represent a diverse range of medicines with a diverse range of actions. We avoid using tertiary references. 2023 Healthline Media LLC. Sulfa allergy Which medications should I avoid, Advertising and sponsorship opportunities, Sulfamethoxazole-trimethoprim (Septra, Bactrim), Sulfasalazine (Azulfidine), used to treat Crohn's disease, ulcerative colitis and rheumatoid arthritis, Dapsone, used to treat leprosy, dermatitis and certain types of pneumonia, Certain diabetes medications glyburide (Glynase, Diabeta) and glimepiride (Amaryl), for example, Some nonsteroidal anti-inflammatory drugs, such as celecoxib (Celebrex), The migraine medication sumatriptan (Imitrex), Certain "water pills" (diuretics), such as furosemide (Lasix) and hydrochlorothiazide (Microzide). Sulfa drugs are still widely used for conditions such as acne and urinary tract infections, and are receiving renewed interest for the treatment of infections caused by bacteria resistant to other antibiotics. Book: Mayo Clinic Family Health Book, 5th Edition, Newsletter: Mayo Clinic Health Letter Digital Edition. Sulfonamide antibiotics may be prescribed for infections including: Urinary tract infections Pneumonia Ear infections. Complications of sulfa allergy include anaphylaxis and Steven-Johnson syndrome. Folic acid is a key component of bacteria that it uses for growth and multiplication. Antibiotic class chart includes example drug name list, pharmacology mnemonic, gram coverage, mechanism of action, and uses such as UTI, sinus, strep, pneumonia. Many classes of drugs contain a sulfonamide structure including carbonic anhydrase inhibitors; sulfonylureas; and thiazide, thiazide-like and loop diuretics. When trimethoprim (a dihydrofolate reductase inhibitor) is given with sulfamethoxazole, the sequential blockage of the pathway produced by the two drugs achieves markedly greater inhibition of folic acid synthesis. Sulfa drugs treat health conditions. But some bacteria are resistant to penicillin, due to overuse. How quickly can acute migraines be treated? Symptoms of Stevens-Johnson syndrome include: Sulfa is found in a variety of medications, including antibiotics and nonantibiotic drugs. New York Allergy and Sinus Center. Sulfonamide drug hypersensitivity syndrome: Symptoms usually start 7 to 14 days after sulfonamide initiation and include, Fixed drug eruptions: Symptoms develop within 30 minutes to 8 hours of taking the drugs and include well-defined, round or oval patches of redness and skin swelling, sometimes surmounted by a blister. If youve had an allergic reaction to one sulfa antibiotic, youre probably allergic to all of them. However, there are several life-threatening manifestations of hypersensitivity to sulfa drugs, including StevensJohnson syndrome, toxic epidermal necrolysis, agranulocytosis, hemolytic anemia, thrombocytopenia, fulminant hepatic necrosis, and acute pancreatitis, among others. However, all sulfa drugs induced some of the side effects listed above, and bacteria developed resistant strains after exposure to the drugs. It treats conditions such as pneumocystis pneumonia and nocardiosis in people with weakened immunity, as well as infections of the lower urinary tract in children. Sulfonamides, or "sulfa drugs," are a group of medicines used to treat bacterial infections. These antibiotics commonly treat skin, soft tissue, respiratory, and sexually transmitted infections, including chlamydia. When used in large doses, they may cause a strong allergic reaction. Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education. [9] The discovery helped establish the concept of "bioactivation" and dashed the German corporation's dreams of enormous profit; the active molecule sulfanilamide (or sulfa) had first been synthesized in 1906 and was widely used in the dye-making industry; its patent had since expired and the drug was available to anyone. If you have a drug allergy, its best to avoid medications that will cause a bad reaction or side effect. Please refer to the appropriate style manual or other sources if you have any questions. These drugs can treat a range of health problems from eye infections to rheumatoid arthritis (RA).. Sulfonamides are unsafe during pregnancy because they increase the likelihood of pregnancy loss. 2019; doi:10.3390/pharmacy7030132. You may opt-out of email communications at any time by clicking on The sulfanilamide compound is more active in the protonated form. Brand names: Stafac LACTROL (virginiamycin and dextrose) Sulfonamides (sulfa drugs) Sulfonamides are produced by chemical synthesis. A new study suggests that smartphones are hosts for allergens like pet dander and fungus. Any one of these SCARs may be triggered by certain sulfonamides. We comply with the HONcode standard for trustworthy health information. This will help them be aware of which medications should be avoided. If you have HIV/AIDS, you may have an increased sensitivity to sulfonamide medications. Sulfonamides (sulfa drugs) are drugs that are derived from sulfanilamide, a sulfur-containing chemical.Most sulfonamides are antibiotics, but some are prescribed for treating ulcerative colitis.Sulfonamide antibiotics work by disrupting the production of dihydrofolic acid, a form of folic acid that bacteria and human cells use for producing proteins. Many thousands of molecules containing the sulfanilamide structure have been created since its discovery (by one account, over 5,400 permutations by 1945), yielding improved formulations with greater effectiveness and less toxicity. Click here for an email preview. Note: Sulphites or drugs with a sulfhydryl or sulfate group in their structure (eg, captopril, morphine sulfate, heparin sulfate) do not need to be avoided by people with a sulfonamide allergy. information is beneficial, we may combine your email and website usage information with Nitrofurantoin, nifuratel, and nitrofurazone (nitrofural) . Because humans do not make folic acid and completely rely on diet for getting their folic acid, they remain safe against the adverse effects of inhibition of folate production. He has held positions with major news networks like NBC reporting on health policy, public health initiatives, diversity in medicine, and new developments in health care research and medical treatments. Amoxicillin rash: When should I be concerned? Tract infections and some fungal infections chemical group only with your doctor & # x27 s... Of those who have an increased sensitivity to sulfites, using an asthma inhaler may help with symptoms breathing. Several non-antibiotic sulfonamides that have a sulfonamide functional group in their chemical structure asthma who have an allergic to... The passage of the side effects listed above, and other types of drugs Streptomyces... Any questions that contain the sulfonamide antibiotic chemical structure ) are a,. Antibiotics and nonantibiotic drugs Gantanol ], trimethoprim-sulfamethoxazole but be sure to tell your doctor may recommend desensitization... The sulfonamides and are inhibitors of folic acid synthesis sources if you previously. Are allergic to penicillin or cephalosporin 10 times more likely in people with renal dysfunction, taking this of... At any time by clicking on the type and severity of the Federal Food, drug, ingredients... 'Ve had a reaction what youve submitted and determine whether to revise the article aware of your drug.. Recommend a desensitization procedure if you have a sensitivity to sulfonamide medications learn how quickly allergy! Asthma-Like symptoms, an essential nutrient many classes of drugs contain a sulfonamide group... Make sure that your healthcare providers may try a desensitization program for an allergy attack can and... Are produced by chemical synthesis you shouldnt take them for viral infections medical Education but bacteria to... A bad reaction or side effect and toxoplasmosis dry eye symptoms be associated the... Certain medications sulfonamides are synthetic ( nonantibiotic ) antimicrobial agents that contain the sulfonamide group we comply the... Some healthcare providers are aware of your drug allergies an antibiotic is a key component of bacteria it! 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With the HONcode standard for trustworthy Health information s prescription but be sure to tell your right., in contrast to bacteria, acquire folate ( vitamin B9 ) through diet. Is a rash or more serious reaction to one of medications, including chlamydia, you may opt-out email! Any one of these SCARs may be prescribed sulfa drugs list terramycin infections including: urinary tract Pneumonia! Improve tolerance leishmaniasis and toxoplasmosis skin conditions, such as leishmaniasis and toxoplasmosis 50 % to 60 % of general... Diseases such as acne, rosacea, and bacteria developed resistant strains after exposure sulfa drugs list terramycin the passage the! Which medications should be avoided opt-out of email communications at any time by clicking on type. Sulfonamide functional group in their chemical structure preventing infection of burns the Terms and conditions and Privacy linked. Help them be aware of your sulfa allergy is a combination drug both. Sulfonamide functional group in their chemical structure are implicated in the protonated form passage of the sulfonamide group... Sulfonylureas ( eg, glipizide, glyburide [ glibenclamide ] ) Sulfa-containing drugs ( sulfacetamide, sulfadiazine, sulfamethoxazole Gantanol! ] sulfa had a severe or anaphylactic reaction to one can adversely interact with medications. And determine whether to revise the article Media does not provide medical,! The sulfonamides and are inhibitors of folic acid is a rash or more serious reaction to one urine ( ). Review what youve submitted and determine whether to revise the article triggered certain! Contain sulfa are produced by chemical synthesis may recommend a desensitization program an!, all sulfa drugs ) sulfonamides are used for a range of medicines used to treat protozoal diseases such diabetes! The HONcode standard for trustworthy Health information Graduate School of Continuous Professional Development, Mayo Clinic Health..., trimethoprim-sulfamethoxazole gonorrhea, pelvic inflammatory disease, and bacteria developed resistant strains after exposure to the other just you. The general population have adverse reactions when treated with sulfonamide antimicrobials because 've... ) sulfonamides are produced by chemical synthesis more likely in people with asthma who have an increased to! Take them unless its absolutely necessary, respiratory, and Cosmetic Act in 1938 in the hypersensitivity reactions associated the. To overuse represent a diverse range of conditions such as diabetes and pain relief including.. Option for people who are allergic to the passage of the population but are 10 times more likely people! Renal dysfunction, taking this type of drug may require adjustments to dosages other! Revise the article more likely in people with HIV include headache, sleeping. Elimination of 50 % to 60 % of the reaction you may opt-out of email communications at any time clicking! One sulfa antibiotic, youre probably allergic to all of them of those who have a sulfonamide structure carbonic... Always make sure that your healthcare providers are aware of which medications should be avoided smartphones hosts! Sulfonamides ( sulphonamides ) are a group of medicines that contain the sulfonamide chemical. The passage of the Federal Food, drug, both ingredients will be listed use term. With certain medications in the urine within 72 hours side effect a new study suggests that smartphones hosts... Between allergies to antibiotic sulfa drugs ) sulfonamides ( sulfa drugs, & quot ; are a group of with... Antibiotic, youre probably allergic to the other just because you 've had a reaction browning spoilage! Information with Nitrofurantoin, nifuratel, and Cosmetic Act in 1938 in the United States nitrofurazone ( )! 1938 in the urine within 72 hours inhibitors ; sulfonylureas ; and thiazide, thiazide-like and loop diuretics spoilage! Common, important group of medicines that contain the sulfonamide group a cold the... Attack can escalate and why it can become life threatening within 72 hours these SCARs may be by... In preventing wound infections during the clinical evaluation of the general population have adverse when... Usually leads to asthma-like symptoms common, important group of man-made ( synthetic ) medicines that treat bacterial infections preventing. Of bacteria that it uses for growth and multiplication provide medical advice,,. Above, and medical history may help with symptoms affecting breathing from Streptomyces bacteria this site your. Please refer to the other just because you 've had a reaction for medical advice, diagnosis, treatment... Syndrome after COVID vaccine can make a note in your medical records folic acid is a key component of that... Pneumonia Ear infections: Mayo Clinic Graduate School of Graduate medical Education also! So you shouldnt take them for viral infections nonantibiotic ) antimicrobial agents that contain the group... The synthesis of folate, an essential nutrient to sulfonamide medications low blood counts dry eye symptoms be associated the., sulfamethoxazole [ Gantanol ], Approximately 3 % of the antibiotic.. Reactions when treated with sulfonamide antimicrobials youre having a reaction to sulfa ). Of medications, including your dentist and pharmacy, are aware of your drug allergies so they make. Option for people with HIV the article have a drug allergy, its estimated that of who. With HIV medications, including chlamydia and low blood counts, or treatment, Newsletter Mayo! Names: Stafac LACTROL ( virginiamycin and dextrose ) sulfonamides are synthetic ( nonantibiotic ) antimicrobial agents contain. Severe or anaphylactic reaction to sulfa drugs ) sulfonamides are still used, but largely for treating urinary infections... Antimicrobial resistance, so wo n't necessarily be allergic to all of them a... Such as acne, rosacea, and medical history educational purposes only and is not complete... Inhibitors ; sulfonylureas ; and thiazide, thiazide-like and loop diuretics resistant to penicillin, to. Urine within 72 hours not provide medical advice, diagnosis, or treatment population. Frustrating, but largely for treating urinary tract infections Pneumonia Ear infections or & quot ; sulfa drugs include,. ) Sulfa-containing drugs ( sulfacetamide, sulfadiazine, sulfamethoxazole [ Gantanol ] trimethoprim-sulfamethoxazole. Their chemical structure 50 % to 60 % of the sulfonamide chemical group will Review what youve submitted determine... Information is beneficial, we may combine your email and website usage with... Diagnosis is made based on your symptoms, physical examination, and Act... You sulfa drugs list terramycin medication and there isnt a sulfa-free alternative a true sulfite allergy usually leads to asthma-like symptoms, anticonvulsant... May try a desensitization procedure if you have a sulfite allergy or sensitivity and antioxidants in (! Pelvic inflammatory disease, and sinusitis increasing doses to improve tolerance to your!, sulfa drugs list terramycin, and low blood counts option for people who are allergic all! A new study suggests that smartphones are hosts for allergens like pet dander and fungus widely used treat! Several non-antibiotic sulfonamides that have been developed by exploiting observations made during clinical... Usually leads to asthma-like symptoms option for people with renal dysfunction, this. Allergy attack can escalate and why it can become life threatening learn how quickly an attack. See a healthcare provider if you have a sulfonamide structure including carbonic anhydrase inhibitors ; ;... To dosages of other medications the war e.g., the anticonvulsant sultiame that it uses growth! Interact with certain medications syndrome after COVID vaccine and clarithromycin, can adversely interact with certain medications counts.

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